Systems biology approaches applied to regenerative medicine

McNamara, L. E., Turner, L.-A. and Burgess, K. V. (2015) Systems biology approaches applied to regenerative medicine. Current Pathobiology Reports, 3(1), pp. 37-45. (doi:10.1007/s40139-015-0072-4) (PMID:25722955) (PMCID:PMC4333234)

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Abstract

Systems biology is the creation of theoretical and mathematical models for the study of biological systems, as an engine for hypothesis generation and to provide context to experimental data. It is underpinned by the collection and analysis of complex datasets from different biological systems, including global gene, RNA, protein and metabolite profiles. Regenerative medicine seeks to replace or repair tissues with compromised function (for example, through injury, deficiency or pathology), in order to improve their functionality. In this paper, we will address the application of systems biology approaches to the study of regenerative medicine, with a particular focus on approaches to study modifications to the genome, transcripts and small RNAs, proteins and metabolites.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Burgess, Dr Karl and McNamara, Dr Laura and Turner, Dr Lesley-Anne
Authors: McNamara, L. E., Turner, L.-A., and Burgess, K. V.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Current Pathobiology Reports
Publisher:Springer US
ISSN:2167-485X
ISSN (Online):2167-485X
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in Current Pathobiology Reports 3(1):37-45
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
608751Dynamic surfaces to mimic mesenchymal stem cell niche functionsMatthew DalbyBiotechnology and Biological Sciences Research Council (BBSRC)BB/K006908/1RI MOLECULAR CELL & SYSTEMS BIOLOGY