McNamara, L. E., Turner, L.-A. and Burgess, K. V. (2015) Systems biology approaches applied to regenerative medicine. Current Pathobiology Reports, 3(1), pp. 37-45. (doi: 10.1007/s40139-015-0072-4) (PMID:25722955) (PMCID:PMC4333234)
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Abstract
Systems biology is the creation of theoretical and mathematical models for the study of biological systems, as an engine for hypothesis generation and to provide context to experimental data. It is underpinned by the collection and analysis of complex datasets from different biological systems, including global gene, RNA, protein and metabolite profiles. Regenerative medicine seeks to replace or repair tissues with compromised function (for example, through injury, deficiency or pathology), in order to improve their functionality. In this paper, we will address the application of systems biology approaches to the study of regenerative medicine, with a particular focus on approaches to study modifications to the genome, transcripts and small RNAs, proteins and metabolites.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Burgess, Dr Karl and McNamara, Dr Laura and Turner, Dr Lesley-Anne |
| Authors: | McNamara, L. E., Turner, L.-A., and Burgess, K. V. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
| Journal Name: | Current Pathobiology Reports |
| Publisher: | Springer US |
| ISSN: | 2167-485X |
| ISSN (Online): | 2167-485X |
| Copyright Holders: | Copyright © 2015 The Authors |
| First Published: | First published in Current Pathobiology Reports 3(1):37-45 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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