Patrono, L. V., Bonfante, F., Zanardello, C., Terregino, C., Capua, I. and Murcia, P. R. (2015) Phylogenetically distinct equine influenza viruses show different tropism for the swine respiratory tract. Journal of General Virology, 96(5), pp. 969-974. (doi: 10.1099/vir.0.000049) (PMID:25593159) (PMCID:PMC4631061)
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Abstract
Influenza A viruses circulate in a wide range of animals. H3N8 equine influenza virus (EIV) is an avian-origin virus that has established in dogs as canine influenza virus (CIV) and has also been isolated from camels and pigs. Previous work suggests that adaptive mutations acquired during EIV evolution might have played a role in CIV emergence. Given the potential role of pigs as a source of human infections, we determined the ability of H3N8 EIVs to replicate in pig cell lines and in respiratory explants. We show that evolutionary distinct EIVs display different infection phenotypes along the pig respiratory tract, but not in cell lines. Our results suggest that EIV displays a dynamic host range along its evolutionary history, supporting the view that evolutionary processes play important roles on host range and tropism, and also underscore the utility of using explants cultures to study influenza pathogenesis.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Capua, Professor Ilaria and Murcia, Professor Pablo |
| Authors: | Patrono, L. V., Bonfante, F., Zanardello, C., Terregino, C., Capua, I., and Murcia, P. R. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
| Journal Name: | Journal of General Virology |
| Publisher: | Society for General Microbiology |
| ISSN: | 0022-1317 |
| ISSN (Online): | 1465-2099 |
| Copyright Holders: | Copyright © 2015 The Authors |
| First Published: | First published in Journal of General Virology 96(5):969-974 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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