Longitudinal changes in body mass index in children with craniopharyngioma

Khan, M. J., Humayun, K. N., Donaldson, M., Ahmed, S. F. and Shaikh, M. G. (2015) Longitudinal changes in body mass index in children with craniopharyngioma. Hormone Research in Paediatrics, 82(6), pp. 372-379. (doi: 10.1159/000368798)

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Objective: We investigated the relationship of body mass index at presentation and pituitary status with long-term changes in BMI over a period of 5 years. Study Design: Craniopharyngioma patients (n = 25) attending a tertiary pediatric endocrine center were divided into three groups based on their BMI at presentation [BMI ≥2 standard deviation scores (SDS), 0-1.99 SDS, and <0 SDS) and then analyzed for trends of BMI over a period of up to 5 years. Results: Median (interquartile range) BMI SDS and hypopituitarism at presentation versus at the 5-year follow-up were as follows: BMI SDS ≥2 group (n = 10): 3.55 (0.68), 6/10 versus 3.76 (1.13), 8/10; BMI SDS 0-1.99 group (n = 11): 1.68 (1.05), 3/11 versus 1.64 (2.04), 7/11, and BMI SDS <0 group (n = 4): -0.23 (0.93), 2/4 versus 0.61, 4/4. At the 5-year follow-up, 10/10, 7/11, and 1/4 subjects when divided in groups according to BMI at presentation were obese. Conclusions: Our data indicate that obesity at presentation, rather than panhypopituitarism either at or after presentation, predicts obesity 5 years after diagnosis. However, obesity at presentation is not always associated with the subsequent development of panhypopituitarism. Pediatric craniopharyngioma subjects who have BMI SDS ≥2 at presentation require early and aggressive intervention to help prevent the complications of obesity.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Khan, Mr Muhammad and Ahmed, Professor Syed Faisal and Donaldson, Dr Malcolm
Authors: Khan, M. J., Humayun, K. N., Donaldson, M., Ahmed, S. F., and Shaikh, M. G.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Hormone Research in Paediatrics
Publisher:S. Karger AG
ISSN (Online):1663-2826

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