Microrheology with optical tweezers: measuring the relative viscosity of solutions 'at a glance'

Tassieri, M. et al. (2015) Microrheology with optical tweezers: measuring the relative viscosity of solutions 'at a glance'. Scientific Reports, 5, 8831. (doi:10.1038/srep08831) (PMID:25743468) (PMCID:PMC4894396)

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Abstract

We present a straightforward method for measuring the relative viscosity of fluids via a simple graphical analysis of the normalised position autocorrelation function of an optically trapped bead, without the need of embarking on laborious calculations. The advantages of the proposed microrheology method are evident when it is adopted for measurements of materials whose availability is limited, such as those involved in biological studies. The method has been validated by direct comparison with conventional bulk rheology methods, and has been applied both to characterise synthetic linear polyelectrolytes solutions and to study biomedical samples.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Tassieri, Dr Manlio and Glidle, Dr Andrew and Cooper, Professor Jonathan
Authors: Tassieri, M., Del Giudice, F., Robertson, E., Jain, N., Fries, B., Wilson, R., Glidle, A., Greco, F., Netti, P. A., Maffettone, P. L., Bicanic, T., and Cooper, J. M.
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Scientific Reports
Publisher:Nature Publishing Group
ISSN:2045-2322
ISSN (Online):2045-2322
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in Scientific Reports 5:8831
Publisher Policy:Reproduced under a Creative Commons License
Data DOI:10.5525/gla.researchdata.156

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
534472Rheology at the Microscale: New Tools for Bio-analysisManlio TassieriEngineering & Physical Sciences Research Council (EPSRC)10216/101ENG - BIOMEDICAL ENGINEERING