Evaluation of biochemical parameters, local and systemic levels of osteoactive and B cell stimulatory factors in gestational diabetes in the presence or absence of gingivitis

Gümüş, P., Ozçaka, O., Ceyhan-Öztürk, B., Akcali, A., Lappin, D. F. and Buduneli, N. (2015) Evaluation of biochemical parameters, local and systemic levels of osteoactive and B cell stimulatory factors in gestational diabetes in the presence or absence of gingivitis. Journal of Periodontology, 86(3), pp. 387-397. (doi: 10.1902/jop.2014.140444) (PMID:25494659)

Abstract

Aim: Gestational diabetes mellitus (GDM) is defined as varying glucose intolerance with first onset or recognition in pregnancy. This study evaluated clinical and biochemical parameters in a possible association between GDM and gingivitis.<p></p> Materials & Methods: A total of 167 pregnant women were included in the study. There were 101 women with GDM and 66 women without GDM. Subgroups were created according to the presence or absence of gingival inflammation. Plaque index, bleeding on probing, probing depth were recorded at 4 sites/tooth. Serum, saliva, and gingival crevicular fluid (GCF) levels of interleukin-6 (IL-6), IL-8, soluble receptor activator of nuclear factor-kappa B ligand (sRANKL), osteoprotegerin, B-cell activating factor (BAFF), a proliferation-inducing ligand (APRIL) were determined by ELISA. Data were analyzed by Kruskal-Wallis, Mann-Whitney U tests, and Spearman correlation analysis.<p></p> Results: Age and anthropometric indices were higher in the GDM than nonGDM group (p<0.0001). Clinical periodontal recordings, serum BAFF, IL-8, saliva sRANKL levels were higher in the GDM group (p<0.05). Saliva IL-6 level was higher in the GDM with gingivitis group than nonGDM with gingivitis (p=0.044). Serum, GCF BAFF (p<0.0001); serum, saliva, GCF APRIL (p<0.0001; p<0.0001; p=0.032, respectively); GCF osteoprotegerin (p=0.036); serum, saliva sRANKL (p<0.0001) were higher in the GDM with gingivitis than GDM without gingivitis.<p></p> Conclusion: The inflammatory response seems to be more pronounced in women with GDM. The observed increase in both local and systemic levels of inflammatory cytokines may suggest an interaction between gingivitis and GDM.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Lappin, Dr David
• Authors: Gümüş, P., Ozçaka, O., Ceyhan-Öztürk, B., Akcali, A., Lappin, D. F., and Buduneli, N.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
• Journal Name: Journal of Periodontology
• Publisher: American Academy of Periodontology
• ISSN: 0022-3492
• ISSN (Online): 1943-3670