A double-blind, placebo-controlled, randomized, crossover trial of a mint tea high in rosmarinic acid in adults with nasal polyposis

Goronfolah, L.T., Ferrie, P., Schmuck, M., Waserman, S., Denburg, J., Kott, L., Keith, P., Crawford, L. and Fletcher, R. (2009) A double-blind, placebo-controlled, randomized, crossover trial of a mint tea high in rosmarinic acid in adults with nasal polyposis. Journal of Allergy and Clinical Immunology, 123(2), S202-S202. (doi: 10.1016/j.jaci.2008.12.771)

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Abstract

RATIONALE: Nasal polyposis is a common chronic inflammatory disease of the nasal mucosa that can have a major impact on patients' lives. Rosmarinic acid is a polyphenolic phytochemical found in a variety of plants including the herbs oregano and rosemary, as well as the mints. It has been found in vitro to have significant antimicrobial and antiviral properties, strong antioxidant and antitumor actions, and some antiallergenic properties.<p></p> METHODS: Adults with bilateral nasal polyps were randomized in a-double-blind, placebo-controlled crossover trial of 1 cup of a mint tea high in rosmarinic acid BID (about 300 mg) vs 1 cup of a mint tea low in rosmarinic acid (about 20 mg) BID. Each treatment period was of 4 weeks duration separated by a 4 week washout period and the first treatment followed a 2 week baseline period.<p></p> RESULTS: 22 subjects completed the study. There was no statistically significant difference between the treatments in terms of nasal stuffiness as recorded on daily diary cards, or in peak nasal inspiratory flows measured twice daily, or in patients' global assessment done at the end of each treatment period. No differences were seen in diary card symptom scores for ability to smell or sleep.<p></p> CONCLUSIONS: Mint tea high in rosmarinic acid 1 cup twice daily for 4 weeks did not improve nasal stuffiness, peak nasal inspiratory flow, sleep, sense of smell or patients' symptoms overall.<p></p>

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Stewart, Ms Lynn
Authors: Goronfolah, L.T., Ferrie, P., Schmuck, M., Waserman, S., Denburg, J., Kott, L., Keith, P., Crawford, L., and Fletcher, R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Allergy and Clinical Immunology
Journal Abbr.:J. Allergy Clin. Immunol.
Publisher:Elsevier
ISSN:0091-6749
ISSN (Online):1097-6825

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