The hidden hand of chloride in hypertension

McCallum, L., Lip, S. and Padmanabhan, S. (2015) The hidden hand of chloride in hypertension. Pflügers Archiv - European Journal of Physiology, 467(3), pp. 595-603. (doi:10.1007/s00424-015-1690-8) (PMID:25619794) (PMCID:PMC4325190)

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Abstract

Among the environmental factors that affect blood pressure, dietary sodium chloride has been studied the most, and there is general consensus that increased sodium chloride intake increases blood pressure. There is accruing evidence that chloride may have a role in blood pressure regulation which may perhaps be even more important than that of Na+. Though more than 85 % of Na+ is consumed as sodium chloride, there is evidence that Na+ and Cl− concentrations do not go necessarily hand in hand since they may originate from different sources. Hence, elucidating the role of Cl− as an independent player in blood pressure regulation will have clinical and public health implications in addition to advancing our understanding of electrolyte-mediated blood pressure regulation. In this review, we describe the evidence that support an independent role for Cl− on hypertension and cardiovascular health.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Lip, Miss Stefanie and Padmanabhan, Professor Sandosh
Authors: McCallum, L., Lip, S., and Padmanabhan, S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Pflügers Archiv - European Journal of Physiology
Publisher:Springer Berlin Heidelberg
ISSN:0031-6768
ISSN (Online):1432-2013
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in Pflügers Archiv - European Journal of Physiology 2015 467(3):595-603
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
664101Serum Chloride - epidemiology and genetic dissection of a novel marker of cardiovascular riskSandosh PadmanabhanBritish Heart Foundation (BHF)FS/14/52/30901RI CARDIOVASCULAR & MEDICAL SCIENCES