McCallum, L., Lip, S. and Padmanabhan, S. (2015) The hidden hand of chloride in hypertension. Pflügers Archiv - European Journal of Physiology, 467(3), pp. 595-603. (doi: 10.1007/s00424-015-1690-8) (PMID:25619794) (PMCID:PMC4325190)
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Abstract
Among the environmental factors that affect blood pressure, dietary sodium chloride has been studied the most, and there is general consensus that increased sodium chloride intake increases blood pressure. There is accruing evidence that chloride may have a role in blood pressure regulation which may perhaps be even more important than that of Na+. Though more than 85 % of Na+ is consumed as sodium chloride, there is evidence that Na+ and Cl− concentrations do not go necessarily hand in hand since they may originate from different sources. Hence, elucidating the role of Cl− as an independent player in blood pressure regulation will have clinical and public health implications in addition to advancing our understanding of electrolyte-mediated blood pressure regulation. In this review, we describe the evidence that support an independent role for Cl− on hypertension and cardiovascular health.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Lip, Dr Stefanie and Padmanabhan, Professor Sandosh |
| Authors: | McCallum, L., Lip, S., and Padmanabhan, S. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Pflügers Archiv - European Journal of Physiology |
| Publisher: | Springer Berlin Heidelberg |
| ISSN: | 0031-6768 |
| ISSN (Online): | 1432-2013 |
| Copyright Holders: | Copyright © 2015 The Authors |
| First Published: | First published in Pflügers Archiv - European Journal of Physiology 2015 467(3):595-603 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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