Protocols for the routine screening of drug sensitivity in the human parasite Trichomonas vaginalis

Natto, M. J., Eze, A. A. and De Koning, H. P. (2015) Protocols for the routine screening of drug sensitivity in the human parasite Trichomonas vaginalis. In: Hempel, J. E., Williams, C. H. and Hong, C. C. (eds.) Chemical Biology. Series: Methods in molecular biology (1263). Humana Press: New York, pp. 103-110. ISBN 9781493922680 (doi:10.1007/978-1-4939-2269-7_8)

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Abstract

Trichomonas vaginalis is a sexually transmitted protozoan parasite of humans. Treatment of trichomoniasis is almost completely dependent on the old drug metronidazole and is hampered by resistance. New drug development, like routine screening for drug resistance, has however been hampered by the lack of reliable screening protocols with sufficient throughput. Here we report on two separate in vitro protocols that use fluorescent dyes and allow for standardized drug sensitivity testing on the required scale.

Item Type:Book Sections
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:De Koning, Professor Harry and Natto, Dr Manal
Authors: Natto, M. J., Eze, A. A., and De Koning, H. P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Methods in Molecular Biology
Publisher:Humana Press
ISSN:1064-3745
ISBN:9781493922680
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