Risk assessment and predicting outcomes in patients with depressive symptoms: a review of potential role of peripheral blood based biomarkers

Jani, B. D. , McLean, G., Nicholl, B. I. , Barry, S. J.E., Sattar, N. , Mair, F. S. and Cavanagh, J. (2015) Risk assessment and predicting outcomes in patients with depressive symptoms: a review of potential role of peripheral blood based biomarkers. Frontiers in Human Neuroscience, 9(Art 18), (doi:10.3389/fnhum.2015.00018)

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Abstract

Depression is one of the major global health challenges and a leading contributor of health related disability and costs. Depression is a heterogeneous disorder and current methods for assessing its severity in clinical practice rely on symptom count, however this approach is unreliable and inconsistent. The clinical evaluation of depressive symptoms is particularly challenging in primary care, where the majority of patients with depression are managed, due to the presence of co-morbidities. Current methods for risk assessment of depression do not accurately predict treatment response or clinical outcomes. Several biological pathways have been implicated in the pathophysiology of depression; however, accurate and predictive biomarkers remain elusive. We conducted a systematic review of the published evidence supporting the use of peripheral biomarkers to predict outcomes in depression, using Medline and Embase. Peripheral biomarkers in depression were found to be statistically significant predictors of mental health outcomes such as treatment response, poor outcome and symptom remission; and physical health outcomes such as increased incidence of cardiovascular events and deaths, and all-cause mortality. However, the available evidence has multiple methodological limitations which must be overcome to make any real clinical progress. Despite extensive research on the relationship of depression with peripheral biomarkers, its translational application in practice remains uncertain. In future, peripheral biomarkers identified with novel techniques and combining multiple biomarkers may have a potential role in depression risk assessment but further research is needed in this area.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Nicholl, Dr Barbara and Jani, Dr Bhautesh and Barry, Dr Sarah and Mair, Professor Frances and Cavanagh, Professor Jonathan and McLean, Dr Gary and Sattar, Professor Naveed
Authors: Jani, B. D., McLean, G., Nicholl, B. I., Barry, S. J.E., Sattar, N., Mair, F. S., and Cavanagh, J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > General Practice and Primary Care
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Mental Health and Wellbeing
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
Journal Name:Frontiers in Human Neuroscience
Publisher:Frontiers in Human Neuroscience
ISSN:1662-5161
ISSN (Online):1662-5161
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in Frontiers in Human Neuroscience 9: Art 18
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
599461Exploring the potential role for allostatic load markers in risk assessment of patients presenting with depressive symptomsFrances MairScottish Executive Health Department (SEHHD-CSO)CAF/12/04IHW - GENERAL PRACTICE & PRIMARY CARE