The mechanism of taurine chloramine inhibition of cytokine (interleukin-6, interleukin-8) production by rheumatoid arthritis fibroblast-like synoviocytes.

Kontny, E., Szczepańska, K., Kowalczewski, J., Kurowska, M. , Janicka, I., Marcinkiewicz, J. and Maśliński, W. (2000) The mechanism of taurine chloramine inhibition of cytokine (interleukin-6, interleukin-8) production by rheumatoid arthritis fibroblast-like synoviocytes. Arthritis and Rheumatism, 43(10), pp. 2169-2177.

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Abstract

Tau-Cl inhibition of IL-6 and IL-8 synthesis in FLS from RA patients results from the ability of this compound to diminish the activity of the major transcriptional regulators (NF-kappaB and AP-1), which subsequently reduces the transcription of these cytokine genes.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kurowska-Stolarska, Dr Mariola
Authors: Kontny, E., Szczepańska, K., Kowalczewski, J., Kurowska, M., Janicka, I., Marcinkiewicz, J., and Maśliński, W.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Arthritis and Rheumatism
Publisher:John Wiley & Sons, Inc.
ISSN:0004-3591

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