Kurowska, M. , Rudnicka, W., Maślińska, D. and Maśliński, W. (2002) Expression of IL-15 and IL-15 receptor isoforms in select structures of human fetal brain. Annals of the New York Academy of Sciences, 966, pp. 441-445. (doi: 10.1111/j.1749-6632.2002.tb04245.x)
Full text not currently available from Enlighten.
Abstract
IL-15, a key cytokine linking innate and acquired immunity, is expressed in many cell types and tissues. Recent data indicate constitutive expression of IL-15 in human neural cell lines and tissues. The aim of the present study was to examine the expression patterns of mRNA encoding IL-15 and IL-15 receptor alpha (IL-15Ralpha) isoforms in select structures of human fetal brain. We report that mRNA for IL-15 and IL-15Ralpha isoforms were expressed in all tested brain structures: cerebral cortex, cerebellum, hippocampus, and thalamus. However, the levels of IL-15 and IL-15Ralpha mRNA were higher in the hippocampus and cerebellum in comparison with cortex and thalamus. Moreover, higher levels of cytosol in comparison with membrane-bound IL-15 isoform were present in all brain structures. The constitutive, but distinct, expression of IL-15 and its receptors in select human fetal brain structures suggests that IL-15 plays a role in their development and physiology.
Item Type: | Articles |
---|---|
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Kurowska-Stolarska, Professor Mariola |
Authors: | Kurowska, M., Rudnicka, W., Maślińska, D., and Maśliński, W. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Annals of the New York Academy of Sciences |
Publisher: | Wiley-Blackwell Publishing, Inc. |
ISSN: | 0077-8923 |
ISSN (Online): | 1749-6632 |
University Staff: Request a correction | Enlighten Editors: Update this record