Expression of IL-15 and IL-15 receptor isoforms in select structures of human fetal brain

Kurowska, M. , Rudnicka, W., Maślińska, D. and Maśliński, W. (2002) Expression of IL-15 and IL-15 receptor isoforms in select structures of human fetal brain. Annals of the New York Academy of Sciences, 966, pp. 441-445. (doi:10.1111/j.1749-6632.2002.tb04245.x)

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Abstract

IL-15, a key cytokine linking innate and acquired immunity, is expressed in many cell types and tissues. Recent data indicate constitutive expression of IL-15 in human neural cell lines and tissues. The aim of the present study was to examine the expression patterns of mRNA encoding IL-15 and IL-15 receptor alpha (IL-15Ralpha) isoforms in select structures of human fetal brain. We report that mRNA for IL-15 and IL-15Ralpha isoforms were expressed in all tested brain structures: cerebral cortex, cerebellum, hippocampus, and thalamus. However, the levels of IL-15 and IL-15Ralpha mRNA were higher in the hippocampus and cerebellum in comparison with cortex and thalamus. Moreover, higher levels of cytosol in comparison with membrane-bound IL-15 isoform were present in all brain structures. The constitutive, but distinct, expression of IL-15 and its receptors in select human fetal brain structures suggests that IL-15 plays a role in their development and physiology.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kurowska-Stolarska, Dr Mariola
Authors: Kurowska, M., Rudnicka, W., Maślińska, D., and Maśliński, W.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Annals of the New York Academy of Sciences
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0077-8923
ISSN (Online):1749-6632

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