ESCRT function in cytokinesis: location, dynamics and regulation by mitotic kinases

Bhutta, M. S., McInerny, C. J. and Gould, G. W. (2014) ESCRT function in cytokinesis: location, dynamics and regulation by mitotic kinases. International Journal of Molecular Sciences, 15(12), pp. 21723-21739. (doi: 10.3390/ijms151221723) (PMID:25429432) (PMCID:PMC4284674)

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Abstract

Mammalian cytokinesis proceeds by constriction of an actomyosin ring and furrow ingression, resulting in the formation of the midbody bridge connecting two daughter cells. At the centre of the midbody resides the Flemming body, a dense proteinaceous ring surrounding the interlocking ends of anti-parallel microtubule arrays. Abscission, the terminal step of cytokinesis, occurs near the Flemming body. A series of broad processes govern abscission: the initiation and stabilisation of the abscission zone, followed by microtubule severing and membrane scission—The latter mediated by the endosomal sorting complex required for transport (ESCRT) proteins. A key goal of cell and developmental biologists is to develop a clear understanding of the mechanisms that underpin abscission, and how the spatiotemporal coordination of these events with previous stages in cell division is accomplished. This article will focus on the function and dynamics of the ESCRT proteins in abscission and will review recent work, which has begun to explore how these complex protein assemblies are regulated by the cell cycle machinery.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Gould, Professor Gwyn and McInerny, Dr Chris
Authors: Bhutta, M. S., McInerny, C. J., and Gould, G. W.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:International Journal of Molecular Sciences
Publisher:MDPI AG
ISSN:1422-0067
ISSN (Online):1422-0067
Copyright Holders:Copyright © 2014 The Authors
First Published:First published in International Journal of Molecular Sciences 15(12):21723-21739
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
463021Regulation and role of the Exocyst complex in cytokinesis.Gwyn GouldCancer Research UK (CAN-RES-UK)C25017/A9006RI MOLECULAR CELL & SYSTEMS BIOLOGY
562531Investigation of the role of Syntaxin 16 and mVps45 in cytokinesisGwyn GouldCancer Research UK (CAN-RES-UK)13082RI MOLECULAR CELL & SYSTEMS BIOLOGY