Decreased insulin sensitivity during dietary sodium restriction is not mediated by effects of angiotensin II on insulin action

Perry, C., Palmer, T., Cleland, S., Morton, I., Salt, I. , Petrie, J. , Gould, G. and Connell, J. (2003) Decreased insulin sensitivity during dietary sodium restriction is not mediated by effects of angiotensin II on insulin action. Clinical Science, 105(2), pp. 187-194. (doi:10.1042/CS20020320)

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Abstract

We have previously reported that modest dietary sodium restriction, as advocated in management guidelines for diabetes, may reduce insulin sensitivity. It has since been suggested that this effect may be mediated via cross-talk between insulin and angiotensin II(AII)-stimulated intracellular second messengers. In order to assess the effect of 5 days of modest sodium restriction (to < 80 mmol/day target sodium intake) on insulin sensitivity, 15 healthy males underwent a double-blind, placebo-controlled, randomized, cross-over euglycaemic hyperinsulinaemic clamp study. One phase was supplemented with sodium tablets and the other with matched placebo. Insulin sensitivity (M) was reduced during dietary sodium restriction [median M value, 10.2 mg/kg per min (interquartile range 9.50-13.85) versus 12.8 mg/kg per min (interquartile range 9.60-14.30), P < 0.05]. To elucidate potential mechanisms that may explain this observation, we investigated the effect of All on insulin action in isolated adipocytes obtained from healthy females. No effect of All on insulin-mediated glucose transport or suppression of lipolysis was observed. In conclusion, despite the observation that dietary sodium restriction was associated with a median 15% reduction in insulin sensitivity, we found no evidence of a direct effect of All on insulin action in human adipocytes.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Gould, Professor Gwyn and Salt, Dr Ian and Petrie, Professor John and Palmer, Dr Tim and Connell, Professor John
Authors: Perry, C., Palmer, T., Cleland, S., Morton, I., Salt, I., Petrie, J., Gould, G., and Connell, J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Clinical Science
ISSN:0143-5221

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