Deep brain stimulation in schizophrenia

Kuhn, J., Bodatsch, M., Sturm, V., Lenartz, D., Klosterkötter, J., Uhlhaas, P.J. , Winter, C. and Gruendler, T.O.J. (2014) Deep brain stimulation in schizophrenia. Activitas Nervosa Superior, 56(3), pp. 69-82.

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Deep brain stimulation (DBS) has successfully advanced treatment options of putative therapy-resistant neuropsychiatric diseases. Building on this strong foundation more and more mental disorders in the stadium of therapy-resistance are considered as possible indications for DBS. Especially schizophrenia with its associated severe and difficult to treat symptoms is gaining attention. This attention demands critical questions regarding the assumed mechanisms of DBS and its possible influence on the supposed pathophysiology of schizophrenia. Here we synoptically compare current approaches and theories of DBS and discuss the feasibility of DBS in schizophrenia as well as the transferability from other psychiatric disorders successfully treated with DBS. For this we consider recent advances in animal models of schizophrenic symptoms, results regarding the influence of DBS on dopaminergic transmission as well as data concerning neural oscillation and synchronization. In conclusion the use of DBS for some symptoms of schizophrenia seems to be a promising approach, but the lack of a comprehensive theory of the mechanisms of DBS as well as its impact on schizophrenia might void the use of DBS in schizophrenia at this point.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Uhlhaas, Professor Peter
Authors: Kuhn, J., Bodatsch, M., Sturm, V., Lenartz, D., Klosterkötter, J., Uhlhaas, P.J., Winter, C., and Gruendler, T.O.J.
College/School:College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:Activitas Nervosa Superior
Publisher:Neuroscientia and NC Publishing
ISSN (Online):1802-9698
Copyright Holders:Copyright © 2014 The Authors
First Published:First published in Activitas Nervosa Superior 56(3):69-82
Publisher Policy:Reproduced under a Creative Commons License

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