High-frequency oscillations and the neurobiology of schizophrenia

Uhlhaas, P. J. and Singer, W. (2013) High-frequency oscillations and the neurobiology of schizophrenia. Dialogues in Clinical Neuroscience, 15(3), pp. 301-313.

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Publisher's URL: http://www.dialogues-cns.org/publication/high-frequency-oscillations-and-the-neurobiology-of-schizophrenia/


Neural oscillations at low- and high-frequency ranges are a fundamental feature of large-scale networks. Recent evidence has indicated that schizophrenia is associated with abnormal amplitude and synchrony of oscillatory activity, in particular, at high (beta/gamma) frequencies. These abnormalities are observed during task-related and spontaneous neuronal activity which may be important for understanding the pathophysiology of the syndrome. In this paper, we shall review the current evidence for impaired beta/gamma-band oscillations and their involvement in cognitive functions and certain symptoms of the disorder. In the first part, we will provide an update on neural oscillations during normal brain functions and discuss underlying mechanisms. This will be followed by a review of studies that have examined high-frequency oscillatory activity in schizophrenia and discuss evidence that relates abnormalities of oscillatory activity to disturbed excitatory/inhibitory (E/I) balance. Finally, we shall identify critical issues for future research in this area.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Uhlhaas, Professor Peter
Authors: Uhlhaas, P. J., and Singer, W.
College/School:College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:Dialogues in Clinical Neuroscience
Publisher:Les Laboratoires Servier
ISSN (Online):1958-5969
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