Thalamocortical synchronization and cognition: implications for schizophrenia?

Uhlhaas, P. J. , Roux, F. and Singer, W. (2013) Thalamocortical synchronization and cognition: implications for schizophrenia? Neuron, 77(6), pp. 997-999. (doi: 10.1016/j.neuron.2013.02.033)

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Cognitive deficits are a core dysfunction in schizophrenia. In this issue of Neuron, Parnaudeau et al. (2013) investigated synchronization in thalamocortical pathways in an animal model to address the disconnection between brain regions as a mechanism for working memory impairments in the disorder.implicated dysfunctional neural oscillations in the explanation of cognitive deficits and certain clinical symptoms of schizophrenia. Specifically, we will focus on findings that have examined neural oscillations during 1) perceptual processing, 2) working memory and executive processes and 3) spontaneous activity. The importance of the development of paradigms suitable for human and animal models is discussed as well as the search for mechanistic explanation for oscillatory dysfunctions.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Uhlhaas, Professor Peter
Authors: Uhlhaas, P. J., Roux, F., and Singer, W.
College/School:College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:Neuron
Publisher:Elsevier Inc.
ISSN (Online):1097-4199
Copyright Holders:Copyright © 2014 Elsevier Inc.
First Published:First published in Neuron 77(6):997-999
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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