Kurita, H., Nakajima, T., Yasuda, H., Takashima, K., Mizuno, A., Wilson, J. I. B. and Cunningham, S. (2011) Single-molecule measurement of strand breaks on large DNA induced by atmospheric pressure plasma jet. Applied Physics Letters, 99(19), p. 191504. (doi: 10.1063/1.3660581)
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Publisher's URL: http://dx.doi.org/10.1063/1.3660581
Abstract
We report a single-molecule-based analysis of strand breakages on large DNA molecules induced by an atmospheric pressure plasma jet. We exposed DNA solution to an argon plasma jet; single-molecule observation that involved molecular combing was then used to measure the length of individual DNA molecules. The measuredDNA length showed that plasma exposure caused a marked change in length of DNA molecules. The rate of plasma-induced strand breakage on large random-coiled DNA molecules was determined using a simple mathematical model. For strand breaks on large DNA molecules the rate was estimated.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Cunningham, Dr Samia |
| Authors: | Kurita, H., Nakajima, T., Yasuda, H., Takashima, K., Mizuno, A., Wilson, J. I. B., and Cunningham, S. |
| College/School: | College of Science and Engineering > School of Engineering |
| Journal Name: | Applied Physics Letters |
| Publisher: | American Institute of Physics |
| ISSN: | 0003-6951 |
| ISSN (Online): | 1077-3118 |
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