Development of antivirulence compounds: a biochemical review

Zambelloni, R., Marquez, R. and Roe, A. J. (2015) Development of antivirulence compounds: a biochemical review. Chemical Biology and Drug Design, 85(1), pp. 43-55. (doi: 10.1111/cbdd.12430)

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Abstract

There is an urgent requirement for new anti-infective compounds that can be used to prevent or treat bacterial pathogens. In particular, Gram-negative pathogens, which are most commonly associated with hospital-acquired infections, are of major concern. In this review, we cover recent developments in the screening and testing of new anti-infective compounds that interfere with aspects of bacterial pathogenicity. This so-called antivirulence approach is very different to traditional antibiotic development and testing. Moreover, antivirulence compounds vary considerably in their chemical structures, ranging from small compounds to large natural products. The challenge of understanding the precise mechanism of action of any such compound is also highlighted.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Marquez, Dr Rudi and Roe, Professor Andrew and Zambelloni, Riccardo
Authors: Zambelloni, R., Marquez, R., and Roe, A. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Science and Engineering > School of Chemistry
Journal Name:Chemical Biology and Drug Design
Publisher:John Wiley & Sons Ltd.
ISSN:1747-0277
ISSN (Online):1747-0285

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