Wilson, R., Moor, J., Jenkins, C., Miller, H., Walker, J.J., McLean, M.A., Norman, J. and McInnes, I. B. (2004) Abnormal first trimester serum interleukin 18 levels are associated with a poor outcome in women with a history of recurrent miscarriage. American Journal of Reproductive Immunology, 51(2), pp. 156-159. (doi: 10.1046/j.8755-8920.2003.00126.x) (PMID:14748843)
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Abstract
PROBLEM:<br/> How the maternal immune system adapts to tolerate the fetus is not fully understood, but a successful pregnancy is associated with the production of Th2-type cytokines and miscarriage is associated with the production of Th1-type cytokines. <br/>METHOD OF STUDY:<br/>Levels of interferon (IFN)-gamma, interleukin (IL)-4, IL-12 and IL-18 were measured in serum from 205 pregnant women of whom 115 pregnant women had a history of recurrent miscarriage.<br/> RESULTS:<br/> Compared with healthy pregnant women those who miscarried had increased serum levels of the Th1-associated cytokines IFN-gamma, IL-12 and IL-18.<br/> CONCLUSIONS:<br/> Increased levels of IL-18 appeared to be critical in early pregnancy and were able to discriminate between pregnancies that continued and those that end in miscarriage.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | McInnes, Professor Iain and Jenkins, Mrs Carol and Norman, Professor Jane and Miller, Mrs Helen |
Authors: | Wilson, R., Moor, J., Jenkins, C., Miller, H., Walker, J.J., McLean, M.A., Norman, J., and McInnes, I. B. |
Subjects: | Q Science > QR Microbiology > QR180 Immunology R Medicine > RG Gynecology and obstetrics |
College/School: | College of Medical Veterinary and Life Sciences College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | American Journal of Reproductive Immunology |
ISSN: | 1046-7408 |
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