A complete shikimate pathway in Toxoplasma gondii: an ancient eukaryotic innovation

Campbell, S., Richards, T., Mui, E., Samuel, B., Coggins, J., McLeod, R. and Roberts, C. (2004) A complete shikimate pathway in Toxoplasma gondii: an ancient eukaryotic innovation. International Journal for Parasitology, 34(1), pp. 5-13. (doi: 10.1016/j.ijpara.2003.10.006)

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Abstract

The shikimate pathway is essential for survival of the apicomplexan parasites Plasmodium falciparum, Toxoplasma gondii and Cryptosporidium parvum. As it is absent in mammals it is a promising therapeutic target. Herein, we describe the genes encoding the shikimate pathway enzymes in T. gondii. The molecular arrangement and phylogeny of the proteins suggests homology with the eukaryotic fungal enzymes, including a pentafunctional AROM. Current rooting of the eukaryotic evolutionary tree infers that the fungi and apicomplexan lineages diverged deeply, suggesting that the arom is an ancient supergene present in early eukaryotes and subsequently lost or replaced in a number of lineages.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Coggins, Professor John
Authors: Campbell, S., Richards, T., Mui, E., Samuel, B., Coggins, J., McLeod, R., and Roberts, C.
College/School:College of Medical Veterinary and Life Sciences
Journal Name:International Journal for Parasitology
Publisher:Elsevier
ISSN:0020-7519
ISSN (Online):1879-0135
Published Online:26 November 2003

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