Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case-control studies from 27 countries

Conway, D. I. et al. (2015) Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case-control studies from 27 countries. International Journal of Cancer, 136(5), pp. 1125-1139. (doi:10.1002/ijc.29063) (PMID:24996155) (PMCID:PMC4531373)

Conway, D. I. et al. (2015) Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case-control studies from 27 countries. International Journal of Cancer, 136(5), pp. 1125-1139. (doi:10.1002/ijc.29063) (PMID:24996155) (PMCID:PMC4531373)

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Abstract

Low socioeconomic status has been reported to be associated with head and neck cancer risk. However, previous studies have been too small to examine the associations by cancer subsite, age, sex, global region and calendar time and to explain the association in terms of behavioral risk factors. Individual participant data of 23,964 cases with head and neck cancer and 31,954 controls from 31 studies in 27 countries pooled with random effects models. Overall, low education was associated with an increased risk of head and neck cancer (OR = 2.50; 95% CI = 2.02 – 3.09). Overall one-third of the increased risk was not explained by differences in the distribution of cigarette smoking and alcohol behaviors; and it remained elevated among never users of tobacco and nondrinkers (OR = 1.61; 95% CI = 1.13 – 2.31). More of the estimated education effect was not explained by cigarette smoking and alcohol behaviors: in women than in men, in older than younger groups, in the oropharynx than in other sites, in South/Central America than in Europe/North America and was strongest in countries with greater income inequality. Similar findings were observed for the estimated effect of low versus high household income. The lowest levels of income and educational attainment were associated with more than 2-fold increased risk of head and neck cancer, which is not entirely explained by differences in the distributions of behavioral risk factors for these cancers and which varies across cancer sites, sexes, countries and country income inequality levels.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Macpherson, Professor Lorna and McMahon, Dr Alex and Conway, Professor David
Authors: Conway, D. I., Brenner, D. R., McMahon, A. D., Macpherson, L. M.D., Agudo, A., Ahrens, W., Bosetti, C., Brenner, H., Castellsague, X., Chen, C., Curado, M. P., Curioni, O. A., Dal Maso, L., Daudt, A. W., de Gois Filho, J. F., D'Souza, G., Edefonti, V., Fabianova, E., Fernandez, L., Franceschi, S., Gillison, M., Hayes, R. B., Healy, C. M., Herrero, R., Holcatova, I., Jayaprakash, V., Kelsey, K., Kjaerheim, K., Koifman, S., La Vecchia, C., Lagiou, P., Lazarus, P., Levi, F., Lissowska, J., Luce, D., Macfarlane, T. V., Mates, D., Matos, E., McClean, M., Menezes, A. M., Menvielle, G., Merletti, F., Morgenstern, H., Moysich, K., Müller, H., Muscat, J., Olshan, A. F., Purdue, M. P., Ramroth, H., Richiardi, L., Rudnai, P., Schantz, S., Schwartz, S. M., Shangina, O., Simonato, L., Smith, E., Stucker, I., Sturgis, E. M., Szeszenia-Dabrowska, N., Talamini, R., Thomson, P., Vaughan, T. L., Wei, Q., Winn, D. M., Wunsch-Filho, V., Yu, G.-P., Zhang, Z.-F., Zheng, T., Znaor, A., Boffetta, P., Chuang, S.-C., Ghodrat, M., Amy Lee, Y.-C., Hashibe, M., and Brennan, P.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:International Journal of Cancer
Publisher:John Wiley and Sons
ISSN:0020-7136
ISSN (Online):1097-0215
Published Online:22 August 2014
Copyright Holders:Copyright © 2014 UICC
First Published:First published in International Journal of Cancer 136(5): 1125-1139
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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