Culpan, D., MacGowan, S.H., Ford, J.M., Nicoll, J.A.R., Griffin, W.S., Dewar, D., Cairns, N.J., Hughes, A., Kehoe, P.G. and Wilcock, G.K. (2003) Tumour necrosis factor-alpha gene polymorphisms and Alzheimer's disease. Neuroscience Letters, 350(1), pp. 61-65. (doi: 10.1016/S0304-3940(03)00854-1)
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Abstract
Recent findings suggest that production of pro-inflammatory cytokines, such as tumour necrosis factor-alpha (TNF-α), is increased in the brains of people with Alzheimer's disease (AD). We used direct sequencing methods on a section of the enhancer/promoter region and on a smaller fragment located 10.5 kb upstream of the TNF-α gene to respectively examine TNF-α polymorphisms and TNF-a and -b microsatellite alleles in a cohort of 235 post-mortem confirmed AD and 130 control cases. None of the TNF-α point mutations or microsatellite alleles investigated proved to be independent risk factors for AD. However, when −308/A, −238/G and TNF-a2 were examined as a 2-1-2 haplotype, we observed that the absence of that haplotype was significantly associated with AD (P=0.014, Fisher's exact test) suggesting that the 2-1-2 haplotype may be protective against AD.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Dewar, Dr Deborah |
| Authors: | Culpan, D., MacGowan, S.H., Ford, J.M., Nicoll, J.A.R., Griffin, W.S., Dewar, D., Cairns, N.J., Hughes, A., Kehoe, P.G., and Wilcock, G.K. |
| Subjects: | R Medicine > R Medicine (General) |
| College/School: | College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience |
| Journal Name: | Neuroscience Letters |
| Publisher: | Elsevier |
| ISSN: | 0304-3940 |
| Published Online: | 25 August 2003 |
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