Tumour necrosis factor-alpha gene polymorphisms and Alzheimer's disease

Culpan, D., MacGowan, S.H., Ford, J.M., Nicoll, J.A.R., Griffin, W.S., Dewar, D. , Cairns, N.J., Hughes, A., Kehoe, P.G. and Wilcock, G.K. (2003) Tumour necrosis factor-alpha gene polymorphisms and Alzheimer's disease. Neuroscience Letters, 350(1), pp. 61-65. (doi:10.1016/S0304-3940(03)00854-1)

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Abstract

Recent findings suggest that production of pro-inflammatory cytokines, such as tumour necrosis factor-alpha (TNF-α), is increased in the brains of people with Alzheimer's disease (AD). We used direct sequencing methods on a section of the enhancer/promoter region and on a smaller fragment located 10.5 kb upstream of the TNF-α gene to respectively examine TNF-α polymorphisms and TNF-a and -b microsatellite alleles in a cohort of 235 post-mortem confirmed AD and 130 control cases. None of the TNF-α point mutations or microsatellite alleles investigated proved to be independent risk factors for AD. However, when −308/A, −238/G and TNF-a2 were examined as a 2-1-2 haplotype, we observed that the absence of that haplotype was significantly associated with AD (P=0.014, Fisher's exact test) suggesting that the 2-1-2 haplotype may be protective against AD.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Dewar, Dr Deborah
Authors: Culpan, D., MacGowan, S.H., Ford, J.M., Nicoll, J.A.R., Griffin, W.S., Dewar, D., Cairns, N.J., Hughes, A., Kehoe, P.G., and Wilcock, G.K.
Subjects:R Medicine > R Medicine (General)
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Neuroscience Letters
Publisher:Elsevier
ISSN:0304-3940
Published Online:25 August 2003

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