Intra- and inter-generic transfer of pathogenicity island-encoded virulence genes by cos phages

Chen, J., Carpena, N. , Quiles-Puchalt, N. , Ram, G., Novick, R. P. and Penadés, J. R. (2015) Intra- and inter-generic transfer of pathogenicity island-encoded virulence genes by cos phages. ISME Journal, 9(5), pp. 1260-1263. (doi:10.1038/ismej.2014.187) (PMID:25314321) (PMCID:PMC4409152)

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Abstract

Bacteriophage-mediated horizontal gene transfer is one of the primary driving forces of bacterial evolution. The pac-type phages are generally thought to facilitate most of the phage-mediated gene transfer between closely related bacteria, including that of mobile genetic elements-encoded virulence genes. In this study, we report that staphylococcal cos-type phages transferred the Staphylococcus aureus pathogenicity island SaPIbov5 to non-aureus staphylococcal species and also to different genera. Our results describe the first intra- and intergeneric transfer of a pathogenicity island by a cos phage, and highlight a gene transfer mechanism that may have important implications for pathogen evolution.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Penades, Professor Jose R and Carpena Garcia, Miss Nuria and Quiles, Miss Nuria
Authors: Chen, J., Carpena, N., Quiles-Puchalt, N., Ram, G., Novick, R. P., and Penadés, J. R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:ISME Journal
Publisher:Nature Publishing Group
ISSN:1751-7362
ISSN (Online):1751-7370
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