Chen, J., Carpena, N. , Quiles-Puchalt, N., Ram, G., Novick, R. P. and Penadés, J. R. (2015) Intra- and inter-generic transfer of pathogenicity island-encoded virulence genes by cos phages. ISME Journal, 9(5), pp. 1260-1263. (doi: 10.1038/ismej.2014.187) (PMID:25314321) (PMCID:PMC4409152)
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Abstract
Bacteriophage-mediated horizontal gene transfer is one of the primary driving forces of bacterial evolution. The pac-type phages are generally thought to facilitate most of the phage-mediated gene transfer between closely related bacteria, including that of mobile genetic elements-encoded virulence genes. In this study, we report that staphylococcal cos-type phages transferred the Staphylococcus aureus pathogenicity island SaPIbov5 to non-aureus staphylococcal species and also to different genera. Our results describe the first intra- and intergeneric transfer of a pathogenicity island by a cos phage, and highlight a gene transfer mechanism that may have important implications for pathogen evolution.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Penades, Prof Jose R and Carpena Garcia, Miss Nuria and Quiles, Miss Nuria |
| Authors: | Chen, J., Carpena, N., Quiles-Puchalt, N., Ram, G., Novick, R. P., and Penadés, J. R. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | ISME Journal |
| Publisher: | Nature Publishing Group |
| ISSN: | 1751-7362 |
| ISSN (Online): | 1751-7370 |
| Related URLs: |
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