Emergence of CD134 cysteine-rich domain 2 (CRD2)-independent strains of feline immunodeficiency virus (FIV) is associated with disease progression in naturally infected cats

Beczkowski, P. M., Techakriengkrai, N., Logan, N., McMonagle, E., Litster, A., Willett, B. J. and Hosie, M. J. (2014) Emergence of CD134 cysteine-rich domain 2 (CRD2)-independent strains of feline immunodeficiency virus (FIV) is associated with disease progression in naturally infected cats. Retrovirology, 11, p. 95. (doi:10.1186/s12977-014-0095-7) (PMID:25430586) (PMCID:PMC4275942)

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Abstract

<b>Background</b> Feline immunodeficiency virus (FIV) infection is mediated by sequential interactions with CD134 and CXCR4. Field strains of virus vary in their dependence on cysteine-rich domain 2 (CRD2) of CD134 for infection.<p></p> <b>Findings</b> Here, we analyse the receptor usage of viral variants in the blood of 39 naturally infected cats, revealing that CRD2-dependent viral variants dominate in early infection, evolving towards CRD2-independence with disease progression.<p></p> <b>Conclusions</b> These findings are consistent with a shift in CRD2 of CD134 usage with disease progression.<p></p>

Item Type:Articles (Other)
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hosie, Professor Margaret and Willett, Professor Brian and Beczkowski, Dr Pawel and McMonagle, Mrs Elizabeth and Logan, Miss Nicola
Authors: Beczkowski, P. M., Techakriengkrai, N., Logan, N., McMonagle, E., Litster, A., Willett, B. J., and Hosie, M. J.
Subjects:Q Science > QR Microbiology > QR355 Virology
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Retrovirology
Publisher:BioMed Central
ISSN:1742-4690
Copyright Holders:Copyright © 2014 The Authors
First Published:First published in Retrovirology 11:95
Publisher Policy:Reproduced under a Creative Commons License
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
509331Quasispecies evolution in the progression of FIV infectionMargaret HosieWellcome Trust (WELLCOME)088486/Z/09ZMVLS III - CENTRE FOR VIRUS RESEARCH
471561The virus-receptor interaction in lentiviral pathogenesis and immunityBrian WillettWellcome Trust (WELLCOME)084272/Z/07/ZMVLS III - CENTRE FOR VIRUS RESEARCH