Beczkowski, P. M., Techakriengkrai, N., Logan, N., McMonagle, E., Litster, A., Willett, B. J. and Hosie, M. J. (2014) Emergence of CD134 cysteine-rich domain 2 (CRD2)-independent strains of feline immunodeficiency virus (FIV) is associated with disease progression in naturally infected cats. Retrovirology, 11, p. 95. (doi: 10.1186/s12977-014-0095-7) (PMID:25430586) (PMCID:PMC4275942)
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Abstract
<b>Background</b> Feline immunodeficiency virus (FIV) infection is mediated by sequential interactions with CD134 and CXCR4. Field strains of virus vary in their dependence on cysteine-rich domain 2 (CRD2) of CD134 for infection.<p></p> <b>Findings</b> Here, we analyse the receptor usage of viral variants in the blood of 39 naturally infected cats, revealing that CRD2-dependent viral variants dominate in early infection, evolving towards CRD2-independence with disease progression.<p></p> <b>Conclusions</b> These findings are consistent with a shift in CRD2 of CD134 usage with disease progression.<p></p>
| Item Type: | Articles (Other) |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Hosie, Professor Margaret and Willett, Professor Brian and Beczkowski, Dr Pawel and McMonagle, Mrs Linda and Logan, Miss Nicola |
| Authors: | Beczkowski, P. M., Techakriengkrai, N., Logan, N., McMonagle, E., Litster, A., Willett, B. J., and Hosie, M. J. |
| Subjects: | Q Science > QR Microbiology > QR355 Virology |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
| Journal Name: | Retrovirology |
| Publisher: | BioMed Central |
| ISSN: | 1742-4690 |
| Copyright Holders: | Copyright © 2014 The Authors |
| First Published: | First published in Retrovirology 11:95 |
| Publisher Policy: | Reproduced under a Creative Commons License |
| Related URLs: |
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