Regulation of neuronal cdc20 (p55cdc) expression by the plasticity-related transcription factor Zif268

Conway, A.-M., James, A.B., Zang, J. and Morris, B.J. (2007) Regulation of neuronal cdc20 (p55cdc) expression by the plasticity-related transcription factor Zif268. Synapse, 61, pp. 463-468. (doi:10.1002/syn.20387)

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Abstract

Most forms of neuronal plasticity are associated with induction of the transcription factor zif268 (egr1). Down-regulation of cdc20 (p55cdc)—a regulatory protein for the anaphase-promoting complex, which controls access of specific substrates to the proteasome—was observed after transfection of a neuronal cell line with zif268. Treatment of cultured hippocampal neurones with NMDA, which elevates endogenous zif268 levels, also decreased cdc20 levels. Conversely, the levels of cdc20 were found to be increased in the cerebral cortex of mice with targeted deletion of the zif268 gene, when compared with wild-type controls. Our findings indicate that expression of the cdc20 gene is down-regulated by zif268 in neuronal cells, and provide new evidence that altered expression of proteasome-regulatory genes following zif268 induction may be a key component of long-lasting CNS plasticity.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Morris, Professor Brian and James, Dr Allan
Authors: Conway, A.-M., James, A.B., Zang, J., and Morris, B.J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Synapse
Publisher:Wiley-Blackwell
ISSN:0887-4476
ISSN (Online):1098-2396
Published Online:19 March 2007

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