Handel, A., Yates, A. , Pilyugin, S. S. and Antia, R. (2007) Gap junction-mediated antigen transport in immune responses. Trends in Immunology, 28(11), pp. 463-466. (doi: 10.1016/j.it.2007.08.006)
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Publisher's URL: http://dx.doi.org/10.1016/j.it.2007.08.006
Abstract
Communication between cells is a crucial part of the immune response. The importance of cytokines and immunological synapses for this purpose has long been recognized. Connexin-based gap junctions that allow exchange of molecules between adjacent cells also seem to have an important role. Recent work suggests that gap junction-mediated antigen transport might be a mechanism of immune-response regulation. Here, we discuss this idea in more detail and suggest possible ways in which this mechanism might have both positive and negative impacts during an immune response.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Yates, Professor Andrew |
| Authors: | Handel, A., Yates, A., Pilyugin, S. S., and Antia, R. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Trends in Immunology |
| Publisher: | Elsevier |
| ISSN: | 1471-4906 |
| ISSN (Online): | 1471-4981 |
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