Lowe, G. and Rumley, A. (2014) The relevance of coagulation in cardiovascular disease: what do the biomarkers tell us? Thrombosis and Haemostasis, 112(5), pp. 860-867. (doi: 10.1160/TH14-03-0199)
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Abstract
Several haemostatic factors have been associated with incident arterial cardiovascular disease in prospective studies and meta-analyses. Plasma fibrinogen shows a strong and consistent association with risk; however, this may reflect its inflammatory marker status, and causality remains to be proven. The common haemostatic gene polymorphisms for factor II, factor V and the von Willebrand factor: Factor VIII (non-O blood group) show significant associations with coronary heart disease (CHD) risk, consistent with potential causality. Increased D-dimer and t-PA antigen levels are associated with CHD risk, suggesting roles for coagulation activation and endothelial disturbance. There is little evidence for associations with CVD with other haemostatic factors.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Rumley, Dr Ann and Lowe, Professor Gordon |
| Authors: | Lowe, G., and Rumley, A. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Thrombosis and Haemostasis |
| Publisher: | Schattauer GmbH |
| ISSN: | 0340-6245 |
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