Conformational plasticity of the influenza A virus NS1 protein

Hale, B. G. (2014) Conformational plasticity of the influenza A virus NS1 protein. Journal of General Virology, 95(Pt 10), pp. 2099-2105. (doi: 10.1099/vir.0.066282-0) (PMID:24928909)

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Abstract

During infection, the influenza A virus non-structural protein 1 (NS1) interacts with a diverse range of viral and cellular factors to antagonize host antiviral defences and promote viral replication. Here, I review the structural basis for some of these functions and discuss the emerging view that NS1 cannot simply be regarded as a ‘static’ protein with a single structure. Rather, the dynamic property of NS1 to adopt various quaternary conformations is critical for its multiple activities. Understanding NS1 plasticity, and the mechanisms governing this plasticity, will be essential for assessing both fundamental protein function and the consequences of strain-dependent polymorphisms in this important virulence factor.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hale, Dr Benjamin
Authors: Hale, B. G.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Journal of General Virology
Publisher:Society for General Microbiology
ISSN:0022-1317
ISSN (Online):1465-2099

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
604512UBIFLU: Ubiquitin Signalling Pathways Required for Influenza Virus Replication: Biological Characterisation and Identification of Novel Drug TargetsBenjamin HaleWellcome Trust (WELLCOME)100034/Z/12/ZMVLS III - CENTRE FOR VIRUS RESEARCH