Clinical presentation and management of stable coronary artery disease: insights from the international prospective CLARIFY registry - results from the Greek National Cohort

Sbarouni, E., Voudris, V., Georgiadou, P., Hamilos, M., Steg, P. G., Fox, K. M., Greenlaw, N., Ferrari, R. and Vardas, P. E. (2014) Clinical presentation and management of stable coronary artery disease: insights from the international prospective CLARIFY registry - results from the Greek National Cohort. Hellenic Journal of Cardiology, 55, pp. 442-447. (PMID:25432195)

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Publisher's URL: http://www.hellenicjcardiol.com/archive/full_text/2014/6/2014_6_442.pdf

Abstract

Introduction: Coronary artery disease (CAD) is highly prevalent worldwide, yet there is a paucity of data regarding the clinical characteristics and management of outpatients with stable CAD. In this paper, we report the baseline data of the Greek cohort and we compare our national data with the global results of the entire registry, as well as the results from the western European countries.

Methods: CLARIFY is an international, prospective, observational, longitudinal registry of outpatients with stable CAD, defined as prior myocardial infarction or revascularization procedure, evidence of coronary stenosis >50%, or chest pain associated with proven myocardial ischemia. A total of 33,283 patients from 45 countries in 4 continents were enrolled between November 2009 and July 2010; of these, 14,726 were from western European countries (Austria, Belgium, Denmark, France, Germany, Greece, Ireland, Italy, Netherlands, Portugal, Spain, Switzerland and the United Kingdom) and 559 patients were enrolled in Greece.

Results: Compared to their counterparts in western Europe and the entire cohort, Greeks were younger (p<0.0001, p<0.0001, respectively), more predominantly male (p<0.0039, p<0.0001), with a higher body mass index (p<0.0002, p<0.0001) and a larger waist circumference (p<0.0001, p<0.0001), as well as a higher prevalence of family history of CAD (p<0.0008, 0.0005), hyperlipidemia (p<0.0001, p<0.0001) and smoking (p<0.0001, p<0.0001). Noninvasive testing (p<0.0001, p<0.0001, respectively) and coronary angiography (p<0.0001, 0.0013) along with surgical revascularization (CABG) (p<0.0001, 0.0088) were performed more often in Greece. Antiplatelets, b-blockers and lipid lowering medications were used to an equal extent in Greece as in the other two cohorts.

Conclusion: There are substantial differences in demographics, clinical profiles and treatment in patients with stable CAD within the data set, which are also observed for Greek data. Interestingly, these differences are consistent in relation to the global as well as the western European data.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Greenlaw, Miss Nicola
Authors: Sbarouni, E., Voudris, V., Georgiadou, P., Hamilos, M., Steg, P. G., Fox, K. M., Greenlaw, N., Ferrari, R., and Vardas, P. E.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
Journal Name:Hellenic Journal of Cardiology
Publisher:Hellenic Cardiological Society
ISSN:1109-9666
ISSN (Online):2241-5955

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